Molecular assessment of drug resistance in Plasmodium falciparum from Bahr El Gazal Province, Sudan
نویسندگان
چکیده
منابع مشابه
Epidemiological and Clinical Features of Plasmodium falciparum Malaria in United Nations Personnel in Western Bahr el Ghazal State, South Sudan
Western Bahr el Ghazal State is located in northwestern South Sudan, which is a tropical area subject to Plasmodium falciparum malaria epidemics. The aim of this study is to explore the epidemiological and clinical features of Plasmodium falciparum malaria in United Nations personnel stationed in this area. From July 2006 to June 2009, epidemiological data and medical records of 678 patients wi...
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In vivo and in vitro assessments of the response of P. falciparum to chloroquine using WHO standard kits and techniques were carried out in I ran Shahr, Sistan and Baluchestan province of Iran in 1985. In the in vivo assessment, 24 malaria patients treated with chloroquine (25mg/kg over three days) were followed up for one to four weeks. The mean parasite clearance time was 4.3 days and in...
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Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance to novel unrelated antimalarials. To test this hypothesis, different Plasmodium falciparum clones having varying numbers of preexisting resistance mechanisms were treated with two new antimalarial age...
متن کاملIn vitro assessment of drug resistance in Plasmodium falciparum in five States of India
BACKGROUND & OBJECTIVES In vitro assays are an important tool to assess baseline sensitivity and monitor the drug response of Plasmodium falciparum over time and place and, therefore, can provide background information for the development and evaluation of drug policies. This study was aimed at determining the in vitro sensitivity of P. falciparum isolates to antimalarials. METHODS The in vit...
متن کاملinduction of drug resistance in plasmodium falciparum: an intermittent drug exposure method
the production of experimentally induced drug resistance in the laboratory provides valuable opportunities for investigators to study the nature and genetics of drug resistance mechanisms to a given agent, patterns of cross resistance and the mode of action of drugs. at the beginning the continuous drug exposure was chosen as a standard procedure to produce drug— resistant strains of p. falcipa...
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ژورنال
عنوان ژورنال: Tropical Medicine & International Health
سال: 2003
ISSN: 1360-2276
DOI: 10.1046/j.1360-2276.2003.01144.x